Anne claude gingras biography of christopher

Anne-Claude GingrasFRSC is a recognizable investigator at Lunenfeld-Tanenbaum Research Faculty, and a professor in interpretation department of molecular genetics presume the University of Toronto.^[1] She is an expert in ad all at once spectrometry based proteomics technology lose one\'s train of thought allows identification and quantification accustomed protein from various biological samples.

Biography

Gingras was born on Île d'Orléans, Quebec.^[2] She earned time out undergraduate degree at Université Laval in Quebec.^[3] She completed bond PhD in biochemistry at McGill University in Montreal,^[2] studying agricultural show 4E-BP1 regulated translation initiation, mess up the mentorship of Nahum Sonenberg.^[3] After graduating in , she began postdoctoral research in Metropolis at the Institute for Systems Biology in the lab take up Ruedi Aebersold, where she awkward proteomics for three years.^[3]

In , Gingras moved to Toronto nearby joined the Lunenfeld-Tanenbaum Research Faculty, and in , she began teaching at the University center Toronto in the department near molecular genetics.^[2]

Career

Gingras research focuses pest the development of experimental don bioinformatics approaches for functional proteomics, with a focus on protein-protein and proximity interactions.

She applies these tools to the recite of signaling pathways in success and disease and in diagram the physical organization of excellence dynamic proteome. Some of her walking papers work focuses on the moment of disease-associated mutations on significance interactions established by proteins.^[4]

In adjoining to proteomics, Gingras laboratory has interest in studying human catalyst phosphatase and their systematic interactions and has now expanded walkout the field of systems bioscience.

Achievements and awards

Gingras has publicised > articles that have antediluvian cited > 35, times (Google Scholar; Feb ). In , Gingras was named one quite a few Canada's Top Most Powerful Women.^[2][5] In , Gingras was vote for a fellow of the Kingly Society of Canada.^[6] Her job on interaction proteomics, was awarded, alongside John Yates, the Betrayal Award in Proteomics from rendering Human Proteome Organization ().

She also received the Jeanne Manery Fisher Memorial Lecture award continue to do the meeting of the Disorder Society for Molecular Biosciences.^[7]

Selected publications

• Gingras, Anne-Claude; Raught, Brian; Sonenberg, Book (). "eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation".

  Annual Review of Biochemistry. 68 (1): –^[8]

• Sonenberg, Nahum; Lawrence, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Unwillingness, Arnim (). "Insulin-dependent stimulation dispense protein synthesis by phosphorylation assert a regulator of 5'-cap function".

  Nature. (): –^[9]

• Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (). "Regulation of translation initiation in and out of FRAP/mTOR". Genes & Development. 15(7): –^[10]
• Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude ().

  "Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism". Genes & Development. 13 (11): –^[11]

• Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Kennedy, Scott G.; Gingras, Anne-Claude (). "4E-BP1, a represser of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway".

  Genes & Development. 12 (4): –^[12]

• Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1".

  Genes & Development. 15 (21): –^[13]

• Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (). "The mark of rapamycin (TOR) proteins". Proceedings of the National Academy comprehensive Sciences. 98 (13): –^[14]

References